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Recent Research on Polyphenolics in Vision and Eye Health

Kalt W, Hanneken A, Milbury P, Tremblay F. Recent research on polyphenolics in vision and eye health. J Agric Food Chem. 2010;58:4001–7.

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Blueberry Effects on Dark Vision and Recovery after Photobleaching: Placebo-Controlled Crossover Studies

Kalt W, McDonald JE, Fillmore SAE, Tremblay F. Blueberry effects on dark vision and recovery after photobleaching: placebo-controlled crossover studies. J Agric Food Chem. 2014;62:11180–9.

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Prophylactic neuroprotection by blueberry-enriched diet in a rat model of light-induced retinopathy

Tremblay F, Waterhouse J, Nason J, Kalt W. Prophylactic neuroprotection by blueberry-enriched diet in a rat model of light-induced retinopathy. J Nutr Biochem [Internet]. 2013;24:647–55.

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Blueberry Polyphenols do not Improve Bone Mineral Density or Mechanical Properties in Ovariectomized Rats

Cladis, D.P., Swallow, E.A., Allen, M.R. et al. Blueberry Polyphenols do not Improve Bone Mineral Density or Mechanical Properties in Ovariectomized Rats. Calcif Tissue Int 110, 260–265 (2022). https://doi.org/10.1007/s00223-021-00905-5.

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Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1

Domazetovic, V., Marcucci, G., Pierucci, F., Bruno, G., Di Cesare Mannelli, L., Ghelardini, C., Brandi, M.L., Iantomasi, T., Meacci, E. and Vincenzini, M.T. (2019), Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1. FEBS Open Bio, 9: 1082-1096.

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Influence of a Polyphenol-Enriched Protein Powder on Exercise-Induced Inflammation and Oxidative Stress in Athletes: A Randomized Trial Using a Metabolomics Approach

Nieman DC, Gillitt ND, Knab AM, Shanely RA, Pappan KL, Jin F, et al. (2013) Influence of a Polyphenol-Enriched Protein Powder on Exercise-Induced Inflammation and Oxidative Stress in Athletes: A Randomized Trial Using a Metabolomics Approach. PLoS ONE 8(8): e72215.

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Consumption of a Blueberry-Enriched Diet by Women for 6 Weeks Alters Determinants of Human Muscle Progenitor Cell Function

Jamie E Blum, Brandon J Gheller, Sinwoo Hwang, Erica Bender, Mary Gheller, Anna E Thalacker-Mercer, Consumption of a Blueberry-Enriched Diet by Women for 6 Weeks Alters Determinants of Human Muscle Progenitor Cell Function, The Journal of Nutrition; 2020: V150: 9; 2412-2418,

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The Protective Effects of a Polyphenol-Enriched Protein Powder on Exercise-Induced Susceptibility to Virus Infection

Ahmed M., Henson D. A., Sanderson M. C., Nieman D. C., Gillitt N. D. and Lila M. A. (2014), The Protective Effects of a Polyphenol-Enriched Protein Powder on Exercise-Induced Susceptibility to Virus Infection, Phytother. Res., 28, pages 1829–1836, doi: 10.1002/ptr.5208.

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Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial.

Wood E, Hein S, Mesnage R, Fernandes F, Abhayaratne N, Xu Y, Zhang Z, Bell L, Williams C, Rodriguez-Mateos A. Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial. Am J Clin Nutr [Internet]. United States; 2023;117:1306–19.

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Effects of Wild Blueberries on Fat Oxidation Rates in Aerobically Trained Males.

Pilolla KD, Armendariz J, Burrus BM, Baston DS, McCarthy KA, Bloedon TK. Effects of Wild Blueberries on Fat Oxidation Rates in Aerobically Trained Males. Nutrients [Internet]. Switzerland; 2023;15.

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Six-month intervention with wild blueberries improved speed of processing in mild cognitive decline: a double-blind, placebo-controlled, randomized clinical trial.

Cheatham CL, III LGC, Millsap G, Stegall JM, Chai SC, Sheppard KW, Lila MA. Six-month intervention with wild blueberries improved speed of processing in mild cognitive decline: a double-blind, placebo-controlled, randomized clinical trial. Nutr Neurosci [Internet]. Taylor & Francis; 2022;0:1–15.

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Wild blueberries attenuate risk factors of the metabolic syndrome.

Klimis-Zacas D, Vendrame S, Kristob AS. Wild blueberries attenuate risk factors of the metabolic syndrome. J Berry Res [Internet]. 2016;6:225–36.

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The Role of Berry Consumption on Blood Pressure Regulation and Hypertension: An Overview of the Clinical Evidence.

Vendrame S, Adekeye TE, Klimis-Zacas D. The Role of Berry Consumption on Blood Pressure Regulation and Hypertension: An Overview of the Clinical Evidence. Nutrients [Internet]. Switzerland; 2022;14.

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Berry Dietary Interventions in Metabolic Syndrome: New Insights.

Venturi S, Marino M, Cioffi I, Martini D, Del Bo’ C, Perna S, Riso P, Klimis-Zacas D, Porrini, M. Berry Dietary Interventions in Metabolic Syndrome: New Insights. Nutrients. Switzerland; 2023;15.

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Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial.

Hodges JK, Maiz M, Cao S, Lachcik PJ, Peacock M, McCabe GP, McCabe LD, Cladis DP, Jackson GS, Ferruzzi MG, et al. Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial. Am J Clin Nutr [Internet]. United States; 2023;118:382–90.

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Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trial.

Nieman DC, Sakaguchi CA, Omar AM, Davis KL, Shaffner CE, Strauch RC, Lila MA, Zhang Q. Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trial. Sci Rep [Internet]. England; 2023;13:11976.

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Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics.

Nunes S, Viana SD, Preguiça I, Alves A, Fernandes R, Teodoro JS, Matos P, Figueirinha A, Salgueiro L, André A, et al. Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics. Nutrients [Internet]. 2021;13.

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Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women.

Stull AJ, Cash KC, Johnson WD, Champagne CM, Cefalu WT. Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women. J Nutr [Internet]. 2010;140:1764–8.

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A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects.

Cremonini E, Daveri E, Iglesias DE, Kang J, Wang Z, Gray R, Mastaloudis A, Kay CD, Hester SN, Wood SM, et al. A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects. Redox Biol [Internet]. 2022;51:102273.

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Blueberry anthocyanin intake attenuates the postprandial cardiometabolic effect of an energy-dense food challenge: Results from a double blind, randomized controlled trial in metabolic syndrome participants.

Curtis PJ, Berends L, van der Velpen V, Jennings A, Haag L, Chandra P, Kay CD, Rimm EB, Cassidy A. Blueberry anthocyanin intake attenuates the postprandial cardiometabolic effect of an energy-dense food challenge: Results from a double blind, randomized controlled trial in metabolic syndrome participants. Clin Nutr [Internet]. 2022;41:165–76.

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Daily blueberry consumption for 12 weeks improves endothelial function in postmenopausal women with above-normal blood pressure through reductions in oxidative stress: a randomized controlled trial.

Woolf EK, Terwoord JD, Litwin NS, Vazquez AR, Lee SY, Ghanem N, Michell KA, Smith BT, Grabos LE, Ketelhut NB, et al. Daily blueberry consumption for 12 weeks improves endothelial function in postmenopausal women with above-normal blood pressure through reductions in oxidative stress: a randomized controlled trial. Food Funct [Internet]. England; 2023;14:2621–41.

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Dietary flavonoid intake and weight maintenance: three prospective cohorts of 124,086 US men and women followed for up to 24 years.

Bertoia ML, Rimm EB, Mukamal KJ, Hu FB, Willett WC, Cassidy A. Dietary flavonoid intake and weight maintenance: three prospective cohorts of 124,086 US men and women followed for up to 24 years. BMJ [Internet]. 2016;352:i17.

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Investigation of the impact of blueberries on metabolic factors influencing health.

Istek N, Gurbuz O. Investigation of the impact of blueberries on metabolic factors influencing health. J Funct Foods [Internet]. 2017;38:298–307.

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Blueberry supplementation influences the gut microbiota, inflammation, and insulin resistance in high-fat-diet-fed rats.

Lee S, Keirsey KI, Kirkland R, Grunewald ZI, Fischer JG, de La Serre CB. Blueberry supplementation influences the gut microbiota, inflammation, and insulin resistance in high-fat-diet-fed rats. J Nutr [Internet]. 2018;148:209–19.

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Blueberry proanthocyanidins and anthocyanins improve metabolic health through a gut microbiota-dependent mechanism in diet-induced obese mice.

Morissette A, Kropp C, Songpadith J-P, Junges Moreira R, Costa J, Mariné-Casadó R, Pilon G, Varin T V, Dudonné S, Boutekrabt L, et al. Blueberry proanthocyanidins and anthocyanins improve metabolic health through a gut microbiota-dependent mechanism in diet-induced obese mice. Am J Physiol Metab [Internet]. 2020;318:E965–80.

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Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice.

Rodríguez-Daza M-C, Daoust L, Boutkrabt L, Pilon G, Varin T, Dudonné S, Levy É, Marette A, Roy D, Desjardins Y. Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice. Sci Rep [Internet]. 2020;10:2217.

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Lowbush wild blueberries have the potential to modify gut microbiota and xenobiotic metabolism in the rat colon.

Lacombe A, Li RW, Klimis-Zacas D, Kristo AS, Tadepalli S, Krauss E, Young R, Wu VCH. Lowbush wild blueberries have the potential to modify gut microbiota and xenobiotic metabolism in the rat colon. PLoS One [Internet]. 2013;8:1–8.

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Blueberries and their bioactives in the modulation of oxidative stress, inflammation and cardio/vascular function markers: a systematic review of human intervention studies.

Martini D, Marino M, Venturi S, Tucci M, Klimis-Zacas D, Riso P, Porrini M, Del Bo’ C. Blueberries and their bioactives in the modulation of oxidative stress, inflammation and cardio/vascular function markers: a systematic review of human intervention studies. J Nutr Biochem. United States; 2023;111:109154.

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Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial.

Johnson SA, Figueroa A, Navaei N, Wong A, Kalfon R, Ormsbee LT, Feresin RG, Elam ML, Hooshmand S, Payton ME, et al. Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial. J Acad Nutr Diet [Internet]. 2015;115:369–77.

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Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome—results from a 6-month, double-blind, randomized controlled trial.

Curtis PJ, Velpen V van der, Berends L, Jennings A, Feelisch M, Umpleby AM, Evans M, Fernandez BO, Meiss MS, Minnion M, et al. Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome—results from a 6-month, double-blind, randomized controlled trial. Am J Clin Nutr [Internet]. 2019;108:1–11.

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Anthocyanins, Anthocyanin-Rich Berries, and Cardiovascular Risks: Systematic Review and Meta-Analysis of 44 Randomized Controlled Trials and 15 Prospective Cohort Studies.

Xu L, Tian Z, Chen H, Zhao Y, Yang Y. Anthocyanins, Anthocyanin-Rich Berries, and Cardiovascular Risks: Systematic Review and Meta-Analysis of 44 Randomized Controlled Trials and 15 Prospective Cohort Studies. [Internet]. Frontiers in nutrition. Switzerland; 2021. p. 747884.

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High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women.

Cassidy AA, Mukamal KJ, Liu L, Franz M, Eliassen AH, Rimm EB. High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation [Internet]. United States; 2013;127:188–96.

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Blueberry Supplementation in Midlife for Dementia Risk Reduction.

Krikorian R, Skelton MR, Summer SS, Shidler MD, Sullivan PG. Blueberry Supplementation in Midlife for Dementia Risk Reduction. Nutrients [Internet]. MDPI; 2022;14:1619.

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Enhanced task-related brain activation and resting perfusion in healthy older adults after chronic blueberry supplementation.

Bowtell JL, Aboo-Bakkar Z, Conway ME, Adlam A-LR, Fulford J. Enhanced task-related brain activation and resting perfusion in healthy older adults after chronic blueberry supplementation. Appl Physiol Nutr Metab [Internet]. 2017;42:773–9.

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Enhanced neural activation with blueberry supplementation in mild cognitive impairment.

Boespflug EL, Eliassen JC, Dudley JA, Shidler MD, Kalt W, Summer SS, Stein AL, Stover AN, Krikorian R. Enhanced neural activation with blueberry supplementation in mild cognitive impairment. Nutr Neurosci [Internet]. Taylor & Francis; 2018;21:297–305.

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Blueberry benefits to cognitive function across the lifespan.

Bell L, Williams CM. Blueberry benefits to cognitive function across the lifespan. Int J Food Sci Nutr [Internet]. England; 2021;72:650–2.

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Dietary intakes of berries and flavonoids in relation to cognitive decline.

Devore E, Hee KJ, Breteler M, Grodstein F. Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol [Internet]. 2012;72:135–43.

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Recent Research on the Health Benefits of Blueberries and Their Anthocyanins.

Kalt W, Cassidy A, Howard LR, Krikorian R, Stull AJ, Tremblay F, Zamora-Ros R. Recent Research on the Health Benefits of Blueberries and Their Anthocyanins. Adv Nutr [Internet]. 2019;11:224–36.

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Long-term Dietary Flavonoid Intake and Subjective Cognitive Decline in US Men and Women.

Yeh T-S, Yuan C, Ascherio A, Rosner BA, Willett WC, Blacker D. Long-term Dietary Flavonoid Intake and Subjective Cognitive Decline in US Men and Women. Neurology [Internet]. Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology; 2021;97:e1041–e1056.

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Association of flavonoid-rich foods and flavonoids with risk of all-cause mortality.

Ivey KL, Jensen MK, Hodgson JM, Eliassen AH, Cassidy A, Rimm EB. Association of flavonoid-rich foods and flavonoids with risk of all-cause mortality. British Journal of Nutrition [Internet]. Cambridge University Press; 2017;117:1470–1477.

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