Cardiovascular/Hypertension/Stroke (by Author)
Ahmet, I.; Spangler, E.; Shukitt-Hale, B.; Joseph, J. A.; Ingram, D. K.; Talan, M.,
Survival and cardioprotective benefits of long-term blueberry enriched diet in dilated cardiomyopathy following myocardial infarction in rats. PLoS One 2009, 4, e7975.
http://www.ncbi.nlm.nih.gov/pubmed/19936253
Ahmet, I.; Spangler, E.; Shukitt-Hale, B.; Juhaszova, M.; Sollott, S. J.; Joseph, J. A.; Ingram, D. K.; Talan, M.,
Blueberry-enriched diet protects rat heart from ischemic damage. PLoS One 2009, 4, e5954.
http://www.ncbi.nlm.nih.gov/pubmed/19936253
Ashour, O. M.; Elberry, A. A.; Alahdal, A.; Al Mohamadi, A. M.; Nagy, A. A.; Abdel-Naim, A. B.; Abdel-Sattar, E. A.; Mohamadin, A. M.,
Protective effect of bilberry (Vaccinium myrtillus) against doxorubicin-induced oxidative cardiotoxicity in rats. Medical science monitor : international medical journal of experimental and clinical research 2011, 17, BR110-5.
http://www.ncbi.nlm.nih.gov/pubmed/21455099
Auger, C.; Kim, J. H.; Trinh, S.; Chataigneau, T.; Popken, A. M.; Schini-Kerth, V. B.,
Fruit juice-induced endothelium-dependent relaxations in isolated porcine coronary arteries: evaluation of different fruit juices and purees and optimization of a red fruit juice blend. Food Funct 2011, 2, 245-50.
http://www.ncbi.nlm.nih.gov/pubmed/21779562
Bell, D. R.; Gochenaur, K.,
Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. Journal of applied physiology (Bethesda, Md. : 1985) 2006, 100, 1164-70.
http://jap.physiology.org/content/100/4/1164.full.pdf+html
Bertuglia, S.; Malandrino, S.; Colantuoni, A.,
Effect of Vaccinium myrtillus anthocyanosides on ischaemia reperfusion injury in hamster cheek pouch microcirculation. Pharmacological research : the official journal of the Italian Pharmacological Society 1995, 31, 183-7.
http://www.ncbi.nlm.nih.gov/pubmed/7630857
Bo, C. d.; Kristo, A. S.; Kalea, A. Z.; Ciappellano, S.; Riso, P.; Porrini, M.; Klimis-Zacas, D.,
The temporal effect of a wild blueberry (Vaccinium angustifolium)-enriched diet on vasomotor tone in the Sprague-Dawley rat. Nutrition, Metabolism and Cardiovascular Diseases 2012, 22, 127-132.
http://www.nmcd-journal.com/article/S0939-4753(10)00125-0/abstract
Chenghui, X.; Jie, K.; Jin-Ran, C.; Shanmugam, N.; Badger, T. M.; Xianli, W.,
Phenolic acids are in vivo atheroprotective compounds appearing in the serum of rats after blueberry consumption. Journal of Agricultural and Food Chemistry 2011, 59, 10381-10387.
http://www.ncbi.nlm.nih.gov/pubmed/21866950
Colantuoni, A.; Bertuglia, S.; Magistretti, M. J.; Donato, L.,
Effects of Vaccinium Myrtillus anthocyanosides on arterial vasomotion. Arzneimittel-Forschung 1991, 41, 905-9.
http://www.ncbi.nlm.nih.gov/pubmed/1796918
de Mello, V. D.; Schwab, U.; Kolehmainen, M.; Koenig, W.; Siloaho, M.; Poutanen, K.; Mykkanen, H.; Uusitupa, M.,
A diet high in fatty fish, bilberries and wholegrain products improves markers of endothelial function and inflammation in individuals with impaired glucose metabolism in a randomised controlled trial: the Sysdimet study. Diabetologia 2011, 54, 2755-67.
http://www.ncbi.nlm.nih.gov/pubmed/21870174
Del Bo, C.; Kristo, A. S.; Kalea, A. Z.; Ciappellano, S.; Riso, P.; Porrini, M.; Klimis-Zacas, D.,
The temporal effect of a wild blueberry (Vaccinium angustifolium)-enriched diet on vasomotor tone in the Sprague-Dawley rat. Nutrition, metabolism, and cardiovascular diseases : NMCD 2010.
http://www.ncbi.nlm.nih.gov/pubmed/20709513
Detre, Z.; Jellinek, H.; Miskulin, M.; Robert, A. M.,
Studies on vascular permeability in hypertension: action of anthocyanosides. Clinical physiology and biochemistry 1986, 4, 143-9.
http://www.ncbi.nlm.nih.gov/pubmed/3698472
Elks, C. M.; Reed, S. D.; Mariappan, N.; Shukitt-Hale, B.; Joseph, J. A.; Ingram, D. K.; Francis, J.,
A blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress. PLoS One 2011, 6, e24028.
http://www.ncbi.nlm.nih.gov/pubmed/21949690
Han, G. L.; Li, C. M.; Mazza, G.; Yang, X. G.,
[Effect of anthocyanin rich fruit extract on PGE2 produced by endothelial cells]. Wei sheng yan jiu = Journal of hygiene research 2005, 34, 581-4.
http://www.ncbi.nlm.nih.gov/pubmed/16329602
Hyunsook, K.; Bartley, G. E.; Rimando, A. M.; Yokoyama, W.,
Hepatic gene expression related to lower plasma cholesterol in hamsters fed high-fat diets supplemented with blueberry peels and peel extract. Journal of Agricultural and Food Chemistry 2010, 58, 3984-3991.
http://www.ncbi.nlm.nih.gov/pubmed/20143813
Kalea, A. Z.; Clark, K.; Schuschke, D. A.; Klimis-Zacas, D. J.,
Vascular reactivity is affected by dietary consumption of wild blueberries in the Sprague-Dawley rat. J Med Food 2009, 12, 21-8.
http://www.ncbi.nlm.nih.gov/pubmed/19298192
Kalea, A. Z.; Clark, K.; Schuschke, D. A.; Kristo, A. S.; Klimis-Zacas, D. J.,
Dietary enrichment with wild blueberries (Vaccinium angustifolium) affects the vascular reactivity in the aorta of young spontaneously hypertensive rats. J Nutr Biochem 2009, 19, 19.
http://www.ncbi.nlm.nih.gov/pubmed/19157824
Kalea, A. Z.; Clark, K.; Schuschke, D. A.; Kristo, A. S.; Klimis-Zacas, D. J.,
Dietary enrichment with wild blueberries (Vaccinium angustifolium) affects the vascular reactivity in the aorta of young spontaneously hypertensive rats. J Nutr Biochem 2010, 21, 14-22.
http://www.ncbi.nlm.nih.gov/pubmed/19157824
Kalea, A. Z.; Lamari, F. N.; Theocharis, A. D.; Cordopatis, P.; Schuschke, D. A.; Karamanos, N. K.; Klimis-Zacas, D. J.,
Wild blueberry (Vaccinium angustifolium) consumption affects the composition and structure of glycosaminoglycans in Sprague-Dawley rat aorta. J Nutr Biochem 2006, 17, 109-16.
http://www.ncbi.nlm.nih.gov/pubmed/16111874
Kalt, W.; Foote, K.; Fillmore, S. A.; Lyon, M.; Van Lunen, T. A.; McRae, K. B.,
Effect of blueberry feeding on plasma lipids in pigs. Br J Nutr 2008, 100, 70-8.
http://www.ncbi.nlm.nih.gov/pubmed/18081945
Karlsen, A.; Paur, I.; Bohn, S. K.; Sakhi, A. K.; Borge, G. I.; Serafini, M.; Erlund, I.; Laake, P.; Tonstad, S.; Blomhoff, R.,
Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD. European journal of nutrition 2010, 49, 345-55.
http://www.ncbi.nlm.nih.gov/pubmed/20119859
Kim, H.; Bartley, G. E.; Rimando, A. M.; Yokoyama, W.,
Hepatic gene expression related to lower plasma cholesterol in hamsters fed high-fat diets supplemented with blueberry peels and peel extract. J Agric Food Chem 2010, 58, 3984-91.
http://www.ncbi.nlm.nih.gov/pubmed/20143813
Kristo, A. S.; Kalea, A. Z.; Schuschke, D. A.; Klimis-Zacas, D.,
Wild blueberry diets attenuate phenylephrine (Phe)-induced vasoconstriction via NO-sGC-cGMP signaling, but not the COX pathway in spontaneously hypertensive rats (SHR). The FASEB Journal 2012, 26, 1026.7.
http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/1026.7
Kristo, A. S.; Kalea, A. Z.; Schuschke, D. A.; Klimis-Zacas, D. J.,
A wild blueberry-enriched diet (Vaccinium angustifolium) improves vascular tone in the adult spontaneously hypertensive rat. J Agric Food Chem 2010, 58, 11600-5.
http://www.ncbi.nlm.nih.gov/pubmed/20964405
Kristo, A. S.; Malavaki, C. J.; Lamari, F. N.; Karamanos, N. K.; Klimis-Zacas, D.,
Wild blueberry (V. angustifolium)-enriched diets alter aortic glycosaminoglycan profile in the spontaneously hypertensive rat. J Nutr Biochem 2011.
http://www.ncbi.nlm.nih.gov/pubmed/21925856
Kristo, A. S.; Malavaki, C. J.; Lamari, F. N.; Karamanos, N. K.; Klimis-Zacas, D. J.,
Wild Blueberry (V. angustifolium) Consumption Alters the Composition and Structure of Glycosaminoglycans (GAGs) in Spontaneously Hypertensive Rats (SHR). FASEB J. 2009, 23, 230.7-.
Liang, Y.; Chen, J.; Zuo, Y.; Ma, K. Y.; Jiang, Y.; Huang, Y.; Chen, Z. Y.,
Blueberry anthocyanins at doses of 0.5 and 1 % lowered plasma cholesterol by increasing fecal excretion of acidic and neutral sterols in hamsters fed a cholesterol-enriched diet. European journal of nutrition 2012.
10.1007/s00394-012-0393-6
Lietti, A.; Cristoni, A.; Picci, M.,
Studies on Vaccinium myrtillus anthocyanosides. I. Vasoprotective and antiinflammatory activity. Arzneimittel-Forschung 1976, 26, 829-32.
http://www.ncbi.nlm.nih.gov/pubmed/9100
Logan, B. A.; Hammond, M. P.; Stormo, B. M.,
The French paradox: Determining the superoxide-scavenging capacity of red wine and other beverages. Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology 2008, 36, 39-42.
http://www.ncbi.nlm.nih.gov/pubmed/21591158
Matsunaga, N.; Chikaraishi, Y.; Shimazawa, M.; Yokota, S.; Hara, H.,
Vaccinium myrtillus (Bilberry) Extracts Reduce Angiogenesis In Vitro and In Vivo. Evidence-based complementary and alternative medicine : eCAM 2010, 7, 47-56.
http://www.hindawi.com/journals/ecam/2010/381937/cta/
Matsunaga, N.; Tsuruma, K.; Shimazawa, M.; Yokota, S.; Hara, H.,
Inhibitory actions of bilberry anthocyanidins on angiogenesis. Phytother Res 2010, 24 Suppl 1, S42-7.
http://www.ncbi.nlm.nih.gov/pubmed/19496063
Mauray, A.; Felgines, C.; Morand, C.; Mazur, A.; Scalbert, A.; Milenkovic, D.,
Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice. Nutrition, metabolism, and cardiovascular diseases : NMCD 2012, 22, 72-80.
http://www.ncbi.nlm.nih.gov/pubmed
Mauray, A.; Felgines, C.; Morand, C.; Mazur, A.; Scalbert, A.; Milenkovic, D.,
Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient mice. Genes & nutrition 2010, 5, 343-53.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989366/?tool=pubmed
Mauray, A.; Milenkovic, D.; Besson, C.; Caccia, N.; Morand, C.; Michel, F.; Mazur, A.; Scalbert, A.; Felgines, C.,
Atheroprotective effects of bilberry extracts in apo E-deficient mice. J Agric Food Chem 2009, 57, 11106-11.
http://www.ncbi.nlm.nih.gov/pubmed/19891504
McAnulty, S. R.; McAnulty, L. S.; Morrow, J. D.; Khardouni, D.; Shooter, L.; Monk, J.; Gross, S.; Brown, V.,
Effect of daily fruit ingestion on angiotensin converting enzyme activity, blood pressure, and oxidative stress in chronic smokers. Free Radic Res 2005, 39, 1241-8.
http://www.ncbi.nlm.nih.gov/pubmed/16298751
Murphy-Walsh, G.; Gottschall-Pass, K.; Sweeney-Nixon, M.,
Effect of wild blueberry (Vaccinium angustifolium) juice consumption on cardiovascular and inflammatory markers in male participants. FASEB J. 2009, 23, 563.9-.
Nalliah, R. E.; Phillips, J. S.; Gaier, A. J.; Gochenaur, K. E.; Bell, D. R.,
Experimental in vitro arterial reactivity and tissue culture solutions alter the time-dependent stability of anthocyanins from elderberry, chokeberry, and bilberry extracts. International journal of food sciences and nutrition 2009, 60 Suppl 1, 209-19.
http://www.ncbi.nlm.nih.gov/pubmed/19381994
Neto, C. C.,
Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases. Mol Nutr Food Res 2007, 51, 652-64.
http://www.ncbi.nlm.nih.gov/pubmed/17533651
Norton, C.; Kalea, A. Z.; Harris, P. D.; Klimis-Zacas, D. J.,
Wild blueberry-rich diets affect the contractile machinery of the vascular smooth muscle in the Sprague-Dawley rat. J Med Food 2005, 8, 8-13.
http://www.ncbi.nlm.nih.gov/pubmed/1585720
Ozgurtas, T.; Aydin, I.; Tapan, S.; Avci, O.; Erbil, M. K.,
Bilberry inhibits angiogenesis in chick chorioallontoic membrane. Biofactors 2008, 33, 161-4.
http://www.ncbi.nlm.nih.gov/pubmed/19478419
Persson, I. A.; Persson, K.; Andersson, R. G.,
Effect of Vaccinium myrtillus and its polyphenols on angiotensin-converting enzyme activity in human endothelial cells. J Agric Food Chem 2009, 57, 4626-9.
http://www.ncbi.nlm.nih.gov/pubmed/19441816
Riso, P.; Klimis-Zacas, D.; Del Bo, C.; Martini, D.; Campolo, J.; Vendrame, S.; Moller, P.; Loft, S.; De Maria, R.; Porrini, M.,
Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors. European journal of nutrition 2012.
10.1007/s00394-012-0402-9
http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/627.6
Sakaida, H.; Nagao, K.; Higa, K.; Shirouchi, B.; Inoue, N.; Hidaka, F.; Kai, T.; Yanagita, T.,
Effect of Vaccinium ashei reade leaves on angiotensin converting enzyme activity in vitro and on systolic blood pressure of spontaneously hypertensive rats in vivo. Biosci Biotechnol Biochem 2007, 71, 2335-7.
http://www.ncbi.nlm.nih.gov/pubmed/17827680
Shaughnessy, K. S.; Boswall, I. A.; Scanlan, A. P.; Gottschall-Pass, K. T.; Sweeney, M. I.,
Diets containing blueberry extract lower blood pressure in spontaneously hypertensive stroke-prone rats. Nutr Res 2009, 29, 130-8.
http://www.ncbi.nlm.nih.gov/pubmed/19285604
Shaughnessy, K. S.; Slemmer, J.; Scanlan, A.; Gottschall-Pass, K.; Sweeney-Nixon, m.,
Cranberries, but not blueberries, prolong survival in spontaneously hypertensive stroke-prone rats. FASEB J. 2009, 23, 563.3-.
Takami, Y.; Uto, H.; Takeshita, M.; Kai, H.; Akamatsu, E.; Moriuchi, A.; Hasegawa, S.; Oketani, M.; Ido, A.; Kataoka, H.; Tsubouchi, H.,
Proanthocyanidin derived from the leaves of Vaccinium virgatum suppresses platelet-derived growth factor-induced proliferation of the human hepatic stellate cell line LI90. Hepatol Res 2010, 40, 337-45.
http://www.ncbi.nlm.nih.gov/pubmed/20070402
Tonstad, S.; Klemsdal, T. O.; Landaas, S.; Hoieggen, A.,
No effect of increased water intake on blood viscosity and cardiovascular risk factors. Br J Nutr 2006, 96, 993-6.
http://www.ncbi.nlm.nih.gov/pubmed/17181872
Trumbeckaite, S.; Burdulis, D.; Raudone, L.; Liobikas, J.; Toleikis, A.; Janulis, V.,
Direct Effects of Vaccinium myrtillus L. Fruit Extracts on Rat Heart Mitochondrial Functions. Phytother Res 2012.
www.ncbi.nlm.nih.gov/pubmed/22628017
Tulio, A. Z.; Chang, C.; Edirisinghe, I.; White, K.; Jablonski, J. E.; Banaszewski, K.; Kangath, A.; Tadapaneni, R. K.; Burton-Freeman, B. M.; Jackson, L. S.,
Berry Fruits Modulated Endothelial Cell Migration and Angiogenesis via Phosphoinositide-3 Kinase/Protein Kinase B Pathway In Vitro in Endothelial Cells. J Agric Food Chem 2012.
http://www.ncbi.nlm.nih.gov/pubmed/22448669
Wiseman, W.; Egan, J. M.; Slemmer, J. E.; Shaughnessy, K. S.; Ballem, K.; Gottschall-Pass, K. T.; Sweeney, M. I.,
Feeding blueberry diets inhibits angiotensin II-converting enzyme (ACE) activity in spontaneously hypertensive stroke-prone rats. Canadian journal of physiology and pharmacology 2011, 89, 67-71.
http://www.ncbi.nlm.nih.gov/pubmed/21186379
Wu, X.; Ferguson, M. E.; Wilkes, S. E.; Nagarajan, S.,
Effects of blueberries in prevention of atherosclerosis in ApoE knockout mice. FASEB J. 2009, 23, 723.3-.
Wu, X.; Kang, J.; Xie, C.; Burris, R.; Ferguson, M. E.; Badger, T. M.; Nagarajan, S.,
Dietary blueberries attenuate atherosclerosis in apolipoprotein E-deficient mice by upregulating antioxidant enzyme expression. J Nutr 2010, 140, 1628-32.
http://www.ncbi.nlm.nih.gov/pubmed/20660283
Xie, C.; Kang, J.; Chen, J. R.; Lazarenko, O. P.; Ferguson, M. E.; Badger, T. M.; Nagarajan, S.; Wu, X.,
Lowbush blueberries inhibit scavenger receptors CD36 and SR-A expression and attenuate foam cell formation in ApoE-deficient mice. Food Funct 2011, 2, 588-94.
http://www.ncbi.nlm.nih.gov/pubmed/21952555
Xie, C.; Kang, J.; Chen, J. R.; Nagarajan, S.; Badger, T. M.; Wu, X.,
Phenolic acids are in vivo atheroprotective compounds appearing in the serum of rats after blueberry consumption. J Agric Food Chem 2011, 59, 10381-7.
http://www.ncbi.nlm.nih.gov/pubmed/21866950
Youdim, K. A.; McDonald, J.; Kalt, W.; Joseph, J. A.,
Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults ( small star, filled). J Nutr Biochem 2002, 13, 282-288.
http://www.ncbi.nlm.nih.gov/pubmed/12015158
Zhu, Y.; Xia, M.; Yang, Y.; Liu, F.; Li, Z.; Hao, Y.; Mi, M.; Jin, T.; Ling, W.,
Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals. Clinical chemistry 2011, 57, 1524-33.
http://www.ncbi.nlm.nih.gov/pubmed/21926181
Ziberna, L.; Lunder, M.; Moze, S.; Vanzo, A.; Tramer, F.; Passamonti, S.; Drevensek, G.,
Acute cardioprotective and cardiotoxic effects of bilberry anthocyanins in ischemia-reperfusion injury: beyond concentration-dependent antioxidant activity. Cardiovascular toxicology 2010, 10, 283-94.
http://www.ncbi.nlm.nih.gov/pubmed/20978867
Ziberna, L.; Lunder, M.; Tramer, F.; Drevensek, G.; Passamonti, S.,
The endothelial plasma membrane transporter bilitranslocase mediates rat aortic vasodilation induced by anthocyanins. Nutrition, metabolism, and cardiovascular diseases : NMCD 2011.
